Quantitative and local mouse brain morphometry in longitudinal MRI studies

Introduction Brain morphometry is defined as studying the variations and changes of brain shape, which is key step in monitoring diseases. Brain morphometry is often performed by group-wise comparison between populations of diseased subjects and healthy controls. In earlier work, we presented the Moore-Rayleigh statistical test to quantify local shape differences between groups of transgenic mice. In this work we show that this nonparametric test can be applied to quantify local shape changes over time in a longitudinal study of a single group of mice.